The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
권호 표지

A Study on Synthesis of $^{99m}Tc-HMPAO$ as A Brain Perfusion Agent and Its Distribution

뇌혈류 평가용 $^{99m}Tc-HMPAO$ 합성 및 분포에 관한 연구

  • Lee, Myung-Chul (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Lee, Bum-Woo (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Chung, June-Key (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Cho, Bo-Youn (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Koh, Chang-Soon (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Jeong, Jae-Min (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Yeom, Mi-Kyung (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Hong, Mee-Kyoung (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Choi, Seok-Rye (Central Laboratory, Seoul National University Hospital)
  • 이명철 (서울대학교 의과대학 내과학교실) ;
  • 이범우 (서울대학교 의과대학 내과학교실) ;
  • 정준기 (서울대학교 의과대학 내과학교실) ;
  • 조보연 (서울대학교 의과대학 내과학교실) ;
  • 고창순 (서울대학교 의과대학 내과학교실) ;
  • 정재민 (서울대학병원 핵의학과) ;
  • 염미경 (서울대학병원 핵의학과) ;
  • 홍미경 (서울대학병원 핵의학과) ;
  • 최석례 (서울대학병원 중앙연구실)
  • Published : 1990.11.25
Download PDF
⟨ Previous Next ⟩

Abstract

HM-PAO was synthesized by two step reaction. d, 1-HM-PAO was separated from the racemic product by fractional recrystalization in ethylacetate, and the chemical structure and purity was confirmed by proton NMR spectroscopy. The synthesized 0, 1-HM-PAO was labeled with $^{99m}Tc$ and studied the biodistribution in mice. From the results we could find that liver uptake of synthesized $^{99m}Tc$ d, 1-HM-PAO was higher than that of Amersham kit, but no conspicuous difference was found in brain and other tissues (blood, lung, stomach, intestine, muscle, spleen and kidney).

Keywords