The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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Miniaturized Chromatographic Quality Control of $^{99m}Tc$ Radiopharmaceuticals

Miniaturized Chromatography에 의한 $^{99m}Tc$-표지 방사성의약품의 정도 관리

  • Yeom, Mi-Kyoung (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Jeong, Jae-Min (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Jin, Kwang-Ho (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Cho, Kyu-Jin (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Chung, June-Key (Department of Internal Medicine, Seoul National University College of Medicine) ;
  • Lee, Myung-Chul (Department of Internal Medicine, Seoul National University College of Medicine) ;
  • Koh, Chang-Soon (Department of Internal Medicine, Seoul National University College of Medicine)
  • 염미경 (서울대학교병원 핵의학과) ;
  • 정재민 (서울대학교병원 핵의학과) ;
  • 진광호 (서울대학교병원 핵의학과) ;
  • 조규진 (서울대학교병원 핵의학과) ;
  • 정준기 (서울대학교 의과대학 내과학교실) ;
  • 이명철 (서울대학교 의과대학 내과학교실) ;
  • 고창순 (서울대학교 의과대학 내과학교실)
  • Published : 1990.04.25
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Abstract

The general use of a number of $^{99m}Tc-labelled$ compounds makes the need for good routine quality control procedures, especially the labelling efficiency measurements. The purpose of these study were to measure the labelling efficiency of $^{99m}Tc-labelled$ MDP, DTPA, Tin colloid, and Antimony sulfide colloid using miniaturized paper and instant thin layer chromatography. The chromatographic systems include whatman 3 MM paper and acetone, Gelman ITLC-SG and 0.9% sodium chloride. The chromatographic strips are miniaturized $(1\times10\;cm)$, marked and numbered. Labelling efficiencies of $^{99m}Tc-labelled$ DTPA and Tin colloid were above 98.0%. $^{99m}Tc-labelled$ Antimony sulfide colloid was 90.0%. And labelling efficiency of $^{99m}Tc-labelled$ MDP was 89.0% Coefficient variance of $^{99m}Tc-labelled$ MDP, DTPA, Tin colloid, and Antimony sulfide colloid were 5.14%, 2.06%, 1.82% and 4.90%, respectively. We found that this miniaturized chromatographic quality control was simple and reliable.

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