Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of 4, 5, 6, 7-Tetraphenyl-8-(substituted)-3 (2H)-phthalazinone Derivatives Likely to Posses Antihypertensive Activity

  • F.A. Yassin (Zagazig University, Faculty of Science Department of Chemistry) ;
  • B.E. Bayoumy (Zagazig University, Faculty of Science Department of Chemistry) ;
  • A.F. El-Farargy (Zagazig University, Faculty of Science Department of Chemistry)
  • Published : 1990.02.20
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Abstract

The interaction of tetraphenylphthalic anhydride with o-chlorotoluene under Friedel-Craft condition gives 2-(4-chloro-3-methyl)benzoyl-3,4,5,6-tetraphenyl benzoic acid(1), which on reaction with hydrazine derivatives gave phthalazinones (2a-d). The behaviour of (2a) towards carbon electrophiles and carbon nucleophiles has been investigated. The chlorophthalazinones (4a) also has been synthesized from the action of $PCl_5/POCl_3$ on (2a). The behaviour of (4a) towards nitrogen, and oxygen nucleophiles also have been described.

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