Effect of Supplementation of Fish Oil on Serum Lipid in Young Healthy Females

어유의 섭취가 젊은 여성의 혈청 지질에 미치는 영향

This study was designed to investigate the effect of supplementation of fish oil on serum lipid in young healthy females. Eighteen female college students were divided into 3 groups. Each group fed a typical Korean diet supplemented with 15g, 12g and 9g of fish oil respectively for 1 week. Blood samples were obtained 4 times before supplementation, immediatly after supplementation, 1 week after stopping supplementation and 3 week after stopping supplementation. After 6 week break, the doses of fish oil were interchanged among 3 groups and the experiment was repeated to reduce interindivisual variation. The level of total cholesterol(TC), triglyceride(TG), lipoprotein, high density lipoprotein(HDL)-cholesterol, low density lipoprotein(LDL)-cholesterol in the serum samples were determined immediately after stopping supplementation and then the value compared with those of the before supplementation period. The results obtained are summarised as follows; The serum TC levels decreased significatly(p<0.01) immediately after supplementation of fish oil and 1 week after stopping supplementation. The serum TG levels also decreased significantly(p<0.05) immediately after supplementation of fish oil. The HDL-cholesterol levels increased significantly(p<0.05) at 2 week and 3 weeks after stopping supplementation of fish oil in the 12g and the 15g supplementation groups. The LDL-cholesterol levels decreased significantly(p<0.05) immediately after and 1 week after stopping supplementation of fish oil. The ratio of HDL-C to TC increased significantly(p<0.01) and the ratio of LDL-C to HDL-C, and index of artherogenesity, decreased significantly(p<0.05).

$\omega$-3계의 지방산의 함량이 많은 어유는 혈청 지질을 저하시키므로 동맥경화증의 위험을 감소시킨다고 보고되어 있다. 그러나, 어유의 효과가 식이중 지방함량이 낮은 수준에서더 현저한가에 대해서는 확실히 알려져 있지 않다. 본 연구는 식사중 지방 함량이 서양인보다 적고,CHD의 예견인자가 다른 한국인에게, 실험군에 따라 1일 9g, 12g 및 15g 의 어유를 1주간 투여한후 혈청 지질을 조사한 결과는 다음과 같다. 1) 혈청 TC함량은 어유 투여 후 및 투여 중단 1주째에 유의적인 감소(p<0.01)를 나타내었으며, 혈청 TG함량은 어유 투여 후에 유의적인 감소를 나타내었다. 2) 혈청 지단백질의 전기영동 결과, VLDL함량은 유의적인 변화를 나타내지 않았고, LDL은 투여중단 1주째에 세 군 모두에서 유의적인 감소(p<0,05)를 나타내었으며, HDL은 9g군에서만 유의적인 증가(p<0.05)를 나타내었다. 3) HDL-C함량은 12g군과 15g군에서 투여 중단 1주째 및 투여 중단 3주째에 유의적인 증가(p<0.05)를 나타내었다. LDL-C 함량은 투여 후 유의적인 감소(p<0.05)를 나타내었고, 투여 중단 1주째에 세 군 모두에서 유의적인 감소(p<0.001)를 나타내었다.