Tranceplacental Effect of Air Pollutants in Seoul to inducing Micronuclei from Polychromatic Erythrocytes in Mouse Fetal Liver

서울시 대기오염물질이 마우스태자 간조직 세포의 소핵출현에 미치는 經胎盤 효과

  • 송동빈 (고려대학교 의과대학 예방의학교실 및 환경의학연구소) ;
  • 김수한 (고려대학교 의과대학 예방의학교실 및 환경의학연구소) ;
  • 김영환 (고려대학교 의과대학 예방의학교실 및 환경의학연구소)
  • Published : 1990.05.01

Abstract

To investigate the transplacental cytogenic effect of air pollutants the authors collected samples from Shinchon, Guro, Banpo and Jungnung-dongs in winter season. The air filters were extracted by mixture of benzene and ethanol, then a certain amount of extracted sustance was injected to pregnant mice at 16th day of gestation. From the fetal liver emulsion polychromatic erythrocytes were collected and stained with Giemsa solution. The cytogenic effect was evaluated by micronucleus test by which numbers of polychromatic erythrocytes containing microunclei (MNPCE) per 1, 000 polychromatic erythrocytes could be counted.

Keywords

References

  1. 人口·保健指標 및 統計 韓國人口保健硏究院
  2. Carcinogens in industry and the environment Sontag,J.M.
  3. J. Environ. Sci. health v.A17 Evalution and classification of the potential carcinogenectiy of organic air pollutants Helmes,C.T.(et al)
  4. 주로 그의 檢出의 立場에서 癌과 化學療法 v.12 no.4 發癌物質 森木 兼囊;小泉 明
  5. Mutation Research v.102 Muagenicity of aiborne prticles Fukin,oH.(et al)
  6. Mutation Research v.91 Mutagenic assay of aromatic nitro compounds wih Salmonella typhimurium Tokiwa,H.;Nakagawa,R.;Ohnishi,Y.
  7. Mutation Research v.104 Mutagenic activity of non-volatile organic matter associated wih suspeded matter in urban air Wiest,F.;de Rondia D.;Gielen,G.J.
  8. Mutation Research v.104 Diurnal variations in the mutagenicity airbone particulate organic matter in Californias south coast air basin Pitts,J.N.(et al)
  9. Mutation Research v.74 Induction of sister-chromatid exchange in human cells in vitro by the mutagenic effect of city-smong extract Schurer,C.C.;Manojlivic,N.;Seemayer,N.H
  10. 環境保全協會誌 v.1 no.2 서울市 大氣汚染物質의 突然變異原性 에 關한 調査 車喆換;金永換;金在性
  11. 대기중 부유분진의 돌연변이 원성 및 미량유기오염성분에 관한 분석적연구 張栽然
  12. 大韓保健協會誌 v.14 no.1 大氣汚染物質이 人體淋巴球染色體 變異 및 姉珠染色體分體交煥 에 미치는 硏究 裵恩相;金永煥;車喆換
  13. Proc. Jpn. Acad. v.53 Co-mutagenic action of norharman and harman Naggo,M.;Yahagi,T.;Sugimura,T.
  14. 藥物의 特殊毒性(1) 胎兒毒性과 遺轉毒性 高木博司
  15. Nature v.227 Transplacental effects of chemical mutagens detected by micronucleus test Cole,R.J.;Taylor,N.A.;Arlett,G.F.
  16. 變理原性과 毒性 v.18 小核試驗-變異原檢出을 위한簡便한 in vivo 試驗 菊池康基;山本好一
  17. Science Forum. v.9 人體淋巴球小核驗 新川加奈子;森木兼囊
  18. Mutation Resarcher v.74 The transplacental micronucleus test. Soyel,C.J.;Clark,A.M
  19. Toxicology Forum v.6 no.4 大氣의 變異原性모니터링法 緩藤純雄
  20. Toxicology Forum v.7 no.6 小核試驗
  21. Mutation Research v.113 Short-term tests for tranplacentally active carcinogens, A comparison of SCE and micro nucleus test in mouse foetal liver erythroblasts Cole,R.J.;Cole,J.;Henderson,L.
  22. 大氣汚染測定網(NASN,日本) 浮遊粉塵中의 Benzo(a)Pyrene分析結果報告書 松下秀鶴
  23. 環境汚染物質과 毒性一有機物篇一 山根靖弘;高蒼英伍
  24. Proc. Natl. Acade. Sci v.77 Cultured mouse embryos metabolize benzo(a)pyrene during early gestation, Genetic differences detectable by SCE. Galloway,S.M.;Perry,P.E.;Mensess,J.
  25. Mut. Res. v.31 The micronucleus test Schmid,W.
  26. Mutation Research v.105 Short-term test for tranplacentally active carcinogens multiple-dose regimens in the transplacental micronucleus test Cole,R.J;Aghamohammadi,Z.;Henderson,L.
  27. Mutation Research v.80 Micronucleus formation in fetal and maternal mouse erythroblasts Cole,R.J.;Taylor,N.;Cloe J.
  28. 大氣保全 v.3 no.2 大氣浮遊粒子狀物質中 Benzo(a)pyrne 濃度 관한 硏究 孫東憲;許文寧;南宮鎔