Journal of Chest Surgery
- 제23권4호
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- Pages.646-653
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- 1990
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- 2765-1606(pISSN)
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- 2765-1614(eISSN)
흰쥐의 적출 작업성 심장에서 허혈성 심정지시 Fructose-1.6-diphosphate(FDP)의 심근보호 작용
Improved Myoardial Protection by Addition of Fructose-1.6-diphosphate to Crystalloid Cardioplegic Solution in the Isolated Working Rat Heart
초록
Currently numerous methods are in use for myocardial protection from the ravages of ischemia and hypoxia. This study was designed to compare with FDP-GIK[Group II, n=8] and GIK cardioplegic solution[Group I, n=8] in ability of myocardial protection and was examined in the isolated working rat heart subjected to long period[120 min] of hypothermic[10 - 15K] ischemic arrest with multidose[every 30 min] cardioplegic infusion. During postischemic reperfusion period 20 min, hemodynamic functions[aortic flow, coronary flow, peak aortic pressure, cardiac output, heart rate], biochemical enzymatic & electrical activities were evaluated. The time from onset of reperfusion to the return of regular sinus rhythm was significantly reduced from 87
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