Journal of Chest Surgery
- Volume 23 Issue 4
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- Pages.646-653
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- 1990
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- 2765-1606(pISSN)
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- 2765-1614(eISSN)
Improved Myoardial Protection by Addition of Fructose-1.6-diphosphate to Crystalloid Cardioplegic Solution in the Isolated Working Rat Heart
흰쥐의 적출 작업성 심장에서 허혈성 심정지시 Fructose-1.6-diphosphate(FDP)의 심근보호 작용
Abstract
Currently numerous methods are in use for myocardial protection from the ravages of ischemia and hypoxia. This study was designed to compare with FDP-GIK[Group II, n=8] and GIK cardioplegic solution[Group I, n=8] in ability of myocardial protection and was examined in the isolated working rat heart subjected to long period[120 min] of hypothermic[10 - 15K] ischemic arrest with multidose[every 30 min] cardioplegic infusion. During postischemic reperfusion period 20 min, hemodynamic functions[aortic flow, coronary flow, peak aortic pressure, cardiac output, heart rate], biochemical enzymatic & electrical activities were evaluated. The time from onset of reperfusion to the return of regular sinus rhythm was significantly reduced from 87
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