Archives of Pharmacal Research
- 제13권4호
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- Pages.293-297
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- 1990
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Preparation of Substained-Release Microspheres of Phenylpropanolamine HCI and Their Release Characteristics
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Kim, Chong-Kook
(College of Pharmacy, Seoul National University) ;
- Lee, Kyung-Mi (College of Pharmacy, Seoul National University) ;
- Hwang, Sung-Joo (College of Pharmacy, Seoul National University) ;
- Yoon, Yong-Sang (College of Pharmacy, Seoul National University)
- 발행 : 1990.12.01
초록
Sustained release microspheres containing phenylpropanolamine HCI (PPA) were prepared with acrylic polymer (Eudragit RL/RS) sand hydroxypropylmethylcellulose phthalate (HPMCP) using a emulsion-solvent evaporation method. Magnesium strate was used a smoothing agent for preparation of microspheres. The microspheres obtained were very spherical and free-flowing particles. Scanning electron microscopy showed that microspheres have a smooth surface and a sponage-like internal structure. The dissolution rate of PPA from the microspheres was dependent on the pH of dissolution media. PPA showed faster relase in hP 1. 2 solution than in pH 7.4 solution due to the solubility of PPA. Therefore we prepared new microspheres containing 5% (w/v) HPMCP in order to control the release of PPA. The release rate of PPA from these new microspheres was similar in pH 1.2 and pH 7.4 solution.
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