Thienobenzothiopyranones 111-New 4H-thieno[2,3-b][1]benzothiopyran-4-ones Carrying Different Heterocyclic Moieties of Expected Pharmacological Interest

  • El-Subbagh, H.I. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura) ;
  • El-Emam, A.A. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura) ;
  • El-Ashmawy, M.B. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura) ;
  • Shehata, I.A. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura)
  • 발행 : 1990.03.01

초록

Reaction of 2-formyl-4H-thieno [2, 3-b] benzothiopyran-4-one (1) with different heterocyclic amines afforded the corresponding Schiff's bases (2-4). Diethyl malonate, ethyl cyanoacetate and malononitrile were reached with 1 to afford compounds 5, 7 and 8, respectively. Compound 5 was cyclized to the pyrazolidin-3, 4-dione (6) by the action of hydrazine hydrate, whereas compound 7 was utilized for the synthesis of the thiazolin-4 one derivatives (9-13).

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