Archives of Pharmacal Research
- 제13권1호
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- Pages.24-27
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- 1990
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Thienobenzothiopyranones 111-New 4H-thieno[2,3-b][1]benzothiopyran-4-ones Carrying Different Heterocyclic Moieties of Expected Pharmacological Interest
- El-Subbagh, H.I. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura) ;
- El-Emam, A.A. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura) ;
- El-Ashmawy, M.B. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura) ;
- Shehata, I.A. (Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura)
- 발행 : 1990.03.01
초록
Reaction of 2-formyl-4H-thieno [2, 3-b] benzothiopyran-4-one (1) with different heterocyclic amines afforded the corresponding Schiff's bases (2-4). Diethyl malonate, ethyl cyanoacetate and malononitrile were reached with 1 to afford compounds 5, 7 and 8, respectively. Compound 5 was cyclized to the pyrazolidin-3, 4-dione (6) by the action of hydrazine hydrate, whereas compound 7 was utilized for the synthesis of the thiazolin-4 one derivatives (9-13).