Journal of fish pathology (한국어병학회지)
- Volume 3 Issue 2
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- Pages.81-91
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- 1990
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- 1226-0819(pISSN)
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- 2233-5412(eISSN)
Effect of Gluathione on the Histopathological Changes Caused by Oxidized Diets in the Carp, Cyprinus carpio
산화(酸化)된 사료(飼料)에 의(依)한 잉어의 병리조직학적(病理組織學的) 증상(症狀)과 glutathione 첨가효과(添加效果)
- Min, Eung-Shik (Department of Fish Pathology, National Fisheries University of Pusan) ;
- Chun, Seh-Kyu (Department of Fish Pathology, National Fisheries University of Pusan)
- Published : 1990.12.30
Abstract
Nutritional ceroidosis accompanied with histopathological changes such as myopathy and visceral ceroidosis, was experimentally induced by feeding the oxidized feed with the peroxide value of 98meq/kg, to common carp resulting in some motalities of carp. To see the effect of treacetment survivors of the above fish were orally administered by feeding diets containing daily doses of 3mg and 6mg of glutathione per kg fish for 10 days or 20 days. While control and 3mg dosage group retained viscerral ceroidosis and showed evidence myopathy histo pathologically, the fish treated with 6mg of glutathione for 20days showed obvious reduction of macrophages of ceroid in the viscera.
평균체중(平均體重) 30 g의 향어에 과산화물가(過酸化物價) 98 meq/kg된 배합사료(配合飼料)를 4개월간(個月間) 투여(投與)한 결과(結果) 이들 향어의 간장(肝臟), 비장(脾臟), 신장(腎臟)에는 많은 ceroid가 침착(沈着)되었다. 이를 제거(除去)하기 위하여 glutathione을 첨가(添加)한 사료(飼料)를 투여(投與)하여 그 치료효과(治療效果)를 실험(實驗)하였다. 향어 1kg당 glutathione 유효성분(有效成分)을 1일(日) 3mg 및 6mg 섭취시키고 10일(日) 및 20일(日) 후(後)에 검사(檢査)한 결과(結果) 20일간(日間) 투여(投與)하면 치료효과(治療效果)가 뚜렷함을 알았다. Glutathione을 6 mg, 20일간(日間) 투여(投與)한 향어의 혈액성상(血液性狀)은 hematocrit 값, 총단백질량(總蛋白質量), 총(總) cholesterol량(量), glucose 값이 정상(正常)과 근사(近似)하였으며 비정상치(非正常値)였던 GOT, GPT 값은 정상치(正常値)로 향하여 감소(減少)되었다.
Keywords