Effects of Pyengpaetang Extracts on the Acute Pulmonary Edema induced by Oleic acid in dogs

평폐탕(平肺湯)이 Oleic acid로 유발(誘發)된 가견(家犬)의 급성폐수종(急性肺水腫)에 미치는 영향(影響)

  • Chung, Jae-Woo (Department of Oriental Medicine Graduate School of Won kwang Univ.) ;
  • Han, Sang-Whan (Department of Oriental Medicine Graduate School of Won kwang Univ.) ;
  • Choe, Sun-Ho (Department of Oriental Medicine Graduate School of Won kwang Univ.)
  • Published : 1990.12.31

Abstract

Certain oriental medication have been shown to be effective in decreasing pulmonary vascular resistance and increasing cardiac output in primary pulmonary artery pressure secondary to pulmonary edema. So oleic acid was administered in 14 dogs in order to induce acute lung injury. And we studied the hemodynamics and blood gas changes of Pyengpaetang(50mg, 100mg) with continuous postive pressure was ventilation in pulmonary edema. The pulmonary edema group, arterial oxygenation was improved after 5 and $10cmH_2O$ PEEP(positive end expiratory pressure), but cardiovascular system was depressed. Blood pressure and cardiac output were decreased, and CVP, MP AP, PCWP were increased. In Pyengpaetang(50mg) group, mean aortic pressure was decreased and PCWP(pulmonary capillary wedge pressure) was decreased remarkably, while there was a significant increase in cardiac output. And there was improvement in $PaO_2$ and $PaCO_2$ without hemodynamic changes after applying 5cm $H_2O$ PEEP, but arterial blood gases$(PaO_2,\;PaCO_2)$ were improved, while cardiovascular effects were depressed after cm $H_2O$ PEEP. In Pyengpaetang(100mg) treated group, there was no significant hemodynamic change. But mean pulmonary arterial pressure was significantly increased, and cardiac output was decreased significantly after applying the more degree of PEEP. And blood gases were not changed significantly after applying the more degree of PEEP. The above results suggest that the effects of Pyengpaetang(50mg) group is superior to those of Pyengpaetang(100mg) group on the effects of hemodynamics and gas exchanges in acute lung injury in dogs. So we can conclude that lower degree PEEP 5cm $H_2O$ is more beneficial in Pyengpaetang(50mg) treated group.

Keywords

References

  1. 三百種醫籍錄 賈維城
  2. 中國醫學史 洪元植
  3. 中醫文獻分冊 中醫大事典編輯委員會(編)
  4. 中國醫學大系 v.12 仁齋直指指方論 楊士濠
  5. 實用中醫內科學 黃文車(外)
  6. 東醫寶鑑 許浚
  7. 金궤要略新解 何任
  8. 內科學 李文鎬(등)
  9. 圖光韓藥大論文集 no.???? 喘證有八中 水喘에 對하여 韓相桓
  10. J Appl physiol v.50 Interactions between permeability and hydrostatic pressure in perfused dog's lungs Huchon, G.J.;Hopewell, P.C.;Murray, J.F.
  11. Ann Rev Med v.19 Circulatory adaptation to high altitude Hultgren, H.N.;Grover, R.F.
  12. 淸金降火湯이 Paraquat로 誘發시킨 白鼠의 肺水腫에 미치는影響 辛祖永
  13. 淸肺湯 및 加味淸肺湯이 Oleic acid로 誘發시킨 家兎의 肺水腫과 Guinea pig의 氣管支 平滑筋에 미치는 影響 金炳勳
  14. 家兎의 急性 肺水腫에 미치는 정력散의 影響 張敬善
  15. 黃帝內經素問 未詳;張${\cdot}$馬合註
  16. 醫學入門 李정
  17. 景岳全書(上) 張介賓
  18. 大韓韓醫學會誌 v.3 no.2 喘息의 使用된 藥物의 文獻的 考察 李珩九
  19. 方藥合篇 黃度淵
  20. 臨床本草學 辛民敎
  21. 漢方醫藥大辭典 陳存仁
  22. 漢藥臨床應用 李尙仁(등)
  23. 申氏本草學 申佶求
  24. Introduction to anesthesia Dripps, R.D.;Eckenhoff, J.E.;Vandam, L.D.
  25. Applied respiratory physiology Nunn, J.F.
  26. Surgery v.89 Aspiration Pneumonia : treatment with osmotically active agents Toung, T.J.;Cameron, J.L.;Kimura, T.(et al.)
  27. N Engl J Med v.296 Pulmonary hypertension in severe active respiratory failure Zapol, W.H.;Snider, M.T.
  28. Biventricular function in the adult respiratory distress syndrome. hemodynamic and ventricular function Sibbald, W.J.;Driadger, A.A.;Muers, M.L.(et al.)
  29. Clinical application of respiratory care Shapiro, B.A.;Kacmarek, R.M.(et al.)
  30. Surgery v.94 Aspiration Pneumonia : treatment with pulmonary vasodiators Broe, P.J.;Toung, T.J.K.;Permutt, S.(et al.)
  31. Ann surg v.183 Aspiration Pneumonia : experimental evaluation of albumin and steroid therapy Toung, T.J.K.;Bordos, D.;Benson, D.W.(et al.)
  32. Am J Pathol v.47 Embolic pneumopathy induced by oleic acid Derks, C.M.;Derks, D.J.
  33. Circulation Res v.16 Measurement of pulmonary edema Pearce, M.L.;Yamashita, J.;Beazeil, J.
  34. 痲취 v.32 Hypoxic pulmonary vasoconstriction 宗行万之助
  35. J Appl Physiol v.49 no.2 Continuity of response to hypoxic pulmonary vasoconstriction Marshall, B.E.;Marshall, C.
  36. J Clin Invest v.64 Effect of furosemide in canine low pressure pulmonary adema Ali, J.;Chernick, W.;Wood, L.D.H.
  37. J Clin Invest v.67 Treatment of acute low pressure pulmonary edema in dogs Prewitt, R.M.;McCarthy, J.;Wood, L.D.H.
  38. 서울의대 학술지 v.24 저산소 환경과 운동이 폐상피세포 투과성에 미치는 영향 김광우;김성덕;엄광원(외 1인)
  39. Crit Care Med v.13 Sequential cardiopulmonary changes after oleic acid injury in dog Hoffman, W.F.;Ehrhart, I.C.;Grangeer, W.M.(et al.)
  40. Anesthesiology v.62 Cardiovascular and blood gas responses to ketanserin in canine pulmonary edema induced by oleic acid Koyama, S.;Kiyono, S.;Kayaba, K.(et al.)
  41. J Appl Phyciol v.38 Instability of lung units with low V/Q ratios during $O_2$ breathing Dangker, D.R.;Wagner, P.D.;West, J.B.
  42. Am J Physiol v.228 Nonsustained pulmonary vasoconstriction during acute hypoxia in aneshetized dog Tucker, A.;Reeves, J.T.
  43. Anesthesiology v.52 Changes in venous admixture with alterations of inspired oxygen concentration Quan, S.F.;Kronberg, G.M.;Scholbohm, R.(et al.)
  44. Am Rev Respir Dis v.115 A stable pulmonary edema model in dogs Modell, H.I.;Cheney, F.W.
  45. Am Rev Respir Dis v.256 The effects of expiratory positive airway pressure on the resolution of oleic acid induced lung injury in dogs Luce, J.M.;Robertson, J.;Huang, T.
  46. Anesthesiology v.59 Effects of hydralazine on cardiovascular function in canine low-pressure pulmonary edema Ghignone, M.;Girling, L.;Prewitt, R.M.
  47. Am Rev Respir Dis v.128 Treatment of Canine low pressure pulmonary edema Harrison, W.D.;Raizen, M.;Ghignone, M.(et al.)
  48. Anesthesiology v.58 Pulmonary vasodilator effects of nitroglycerin and sodium nitroprusside in canine oleic acid induced pulmonary hypertension Pearl, R.G.;Rosenthal, M.H.;Ashton, J.P.
  49. 대한마취과학회지 v.19 개에서 급성미만성 폐포저산소중이 심폐혈류 역학 및 조직의 산소섭취에 미치는 영향 한성민;김성덕;김광우
  50. Cirs Res v.20 A Study of the mechanisms involved in the pulmonary artery pressure response to hypoxia Bergofsky, E.H.;Holtzman, M.S.
  51. J Clin Invest v.51 Role of cell swelling in ischemic renal damage and the protective effect of hypertonic solute Flores, J.;DiBona, P.R.;Beck, C.H.(et al.)
  52. Br J Anesth v.53 Depression of hypoxic prulmonary vasoconstriction by sodium nitroprusside and nitroglycerine D'Oiveira, M.;Sykes, M.K.;Chakrabarti, M.K.(et al.)
  53. Ann Surg v.185 Hypertonic mannitol in the therapy of the acute respiratory distress syndrome Powers, S.R.;Shah, D. Jr.;Ryon, D.(et al.)
  54. Anesthesiology v.47 Respiratory intensive care Pontoppidan, H.;Wilson, R.S.;Rie, M.A.(et al.)
  55. Br J Anesth v.54 Adult respiratory distress syndrome Fein, A.M.;Goldberg, S.K.;Lippmann, M.L.(et al.)
  56. High frequency jet ventilation Chiaranda, M.;Giron, G.P.
  57. Aneshesiology v.69 Treatment of noncardiogenic pulmonary edema following cardiopulmonary by pass with veno-venous extracorporeal membrane oxygeration Pilato, M.A.;Fleming, N.W.;Katz, N.M.(et al.)
  58. Clinical application of respiratory care Shapiro, B.A.;Harrison, R.A.;Kacmarek, R.M.(et al.)
  59. Circulation v.66 The effects of airway pressure on cardiac function in intact dog and man Raukia, J.S.;Olseu, C.O.;Arentzen, C.E.(et al.)
  60. N Engl J Med v.304 Influence of positive and expiratory pressure on left ventricular performance Jardin, F.;Farcot, J.B.;Boisante, L.(et al.)
  61. N Engl J Med v.283 Continuous positive-pressure veutilation in acute respiratory failure : effects on hemodynamics and lung function Kumar, A.;Falke, K.J.;Goffin, B.(et al.)
  62. Anesthesiology v.42 Hemodynamic responses to mechanical ventilation with PEEP : the effect of hypervolemia Qvist, J.;Poutoppidan, H.;Wilson, R.S.;Lowenstein, F.;Laver, M.B.
  63. Cir Rev v.5 Alterations in central blood volume and cardiac output induced by positive pressure breathing and counteracted by metaraminol(Aramine) Braunwald, E.;Binion, J.T.;Morgan, W.L.J.O.;Sarnof, S.J.