The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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EFFECTS OF PAI MO SAN WATER EXTRACT ON THE PLASMA CORTISOL CONCENTRACTION AND ARTERIAL BLOOD $PCO_2,\;PO_2$ IN THE RABBIT

패모산(貝母散) 전탕액(煎湯液)이 가토(家兎) 혈장(血漿) Cortisol 농도(濃度) 및 동맥혈(動脈血) $PCO_2,\;PO_2$에 미치는 영향(影響)

  • 최선엽 (원광대학교 한의과대학 폐계내과학교실) ;
  • 한상환 (원광대학교 한의과대학 폐계내과학교실)
  • Published : 1990.03.09
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Abstract

To evaluate effects of Pai Mo San (PMS) water extract on the plasma cortisol concentration and arterial blood $PCO_2,\;PO_2$ in the rabbit. The results obtained were as follows: 1. Intravenous administration of PMS water extract at the dose of 0.2 ml/kg remarkably increased plasma cortisol concentration from 1 to 2 hours. 2. Intravenous administration of PMS water extract at the dose of 0.4 ml/kg plasma cortisol concentration showed more significant increase than the control group after 1,2,4 hours. 3. No change observed in the arterial blood $PO_2$ after intravenous administration of PMS water extract at the dose of 0.2 ml/kg used. 4. No change observed in the arterial blood $PO_2$ after intravenous administration of PMS water extract at the dose of 0.4 ml/kg used. 5. Intravenous administration of PMS water extract at the dose of 0.2 ml/kg arterial blood $PCO_2$ showed more significant decreased than the control group after 1,3 hours. 6. Intravenous administration of PMS water extract at the dose of 0.4 ml/kg significantly decreased arterial blood $PCO_2$. These results suggest that the therapeutic action of Pai Mo San water extract for Yeol Su (熱嗽), Wha Su (火熱), Gu Su (久熱) and anti-asthma maybe related with the increase of plasma cortisol, decrease of $PCO_2$.

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