Applied Biological Chemistry

  • 제33권3호
  • /
  • Pages.264-267
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  • 1990
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  • 2468-0834(pISSN)
  • /
  • 2468-0842(eISSN)
한국응용생명화학회 (The Korean Society for Applied Biological Chemistry)
권호 표지

호습쇄의 NADH-ubiquinone oxidoreductase 저해제인 합성 piericidin유사체드르이 살균활성

Fungicidal activity of synthetic piericidin analogs as inhibitors of NADH-ubiquinone oxidoreductase on the respiratory chain

  • Chung, Kun-Hoe (Organic Div. I, Korea Research Institute of Chemical Technology (KRICT)) ;
  • Cho, Kwang-Yun (Organic Div. I, Korea Research Institute of Chemical Technology (KRICT)) ;
  • Takahashi, Nobutaka (Department of Agricultural Chemistry, The University of Tokyo) ;
  • Yoshida, Shigeo (Chemical Regulation of Biomechanisms Lab., The Institute of Chemical and Physical Research (RIKEN))
  • 발행 : 1990.09.30
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초록

호습쇄의 NADH-ubiquinone oxidoreductase를 강력히 저해하는 합성 piericidin유사체로써 hydroxypyridine 및 hyoxyquinoline 유도체들이 전반적으로 좋은 살균활성을 보였다. 특히, hydroxypyfidine 유도체들은 벼도열병(Pyricularia oryzae)과 보리흰가루병(Erysiphe graminis)에 대해서 높은 살균활성을 나타했다.

Representative synthetic piericidin-like compounds, such as hydroxypyridine and hydroxyquinoline derivatives, which showed high inhibition activity against NADH-ubiquinone oxidoreductase on the respiratory chain revealed good fungicide activity. Especially, hydrolrypyridine ones showed high activity against rice blast (Pyricularia oryzae) and barley powdery mildew (Erysiphe graminis).

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