난용성 약물의 용출 증가(제5보)-포비돈과의 혼합분쇄 또는 공침에 의한 푸로세미드의 용출 증대-

Enhancement of Dissolution Properties of Poorly Soluble Drugs (V)-Enhanced Dissolution of Furosemide by Cogrinding or Coprecipitating with Povidone-

To increase the dissolution rate of furosemide, cogrinding or coprecipitating of furosemide with povidone was carried out. The ground mixture of furosemide with povidone was prepared by cogrinding in a ceramic ball mill and the coprecipitate was prepared by solvent method using methanol. The povidone ground mixture and the coprecipitate showed a faster and more enhanced dissolution rate than the physical mixture or intact furosemide. The IR, DTA and TGA studies showed the physicochemical modifications of furosemide from the ground mixture and the coprecipitate. An interaction, in the ground mixture and in the coprecipitate, such as association between the functional groups of furosemide and povidone might occur in the molecular level. The coprecipitating and cogrinding techniques with povidone provided a promising way to increase the dissolution rate of poorly soluble drugs.