Journal of the Korean Society of Food Culture (한국식생활문화학회지)
- Volume 5 Issue 1
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- Pages.169-180
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- 1990
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- 1225-7060(pISSN)
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- 2288-7148(eISSN)
우유투여가 N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) 유발 위십이지장 암 발생에 미치는 영향에 관한 실험적 연구
초록
An experimental study on the effect of milk diet on carcinogenesis induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) was designed in rats to elucidate its mechanism. A total of 136 Sprague-Dawley rats were divided into 6 groups according to the milk dosagnes in each diet. The entire group of 136 rats was fed the MNNG (100 g/ml) and milk for the initial 28 weeks. Thereafter for the next 12 weeks the group was fed a normal diet only. After this 40 week experiment 109 rats survived. These rats were then dissected with the results being summarized as follows: Suppression of gastroduodenal malignancy was evidenced by the increase of milk concentration in the diet except for the group given MNNG and the lowest concentration of milk (6% milk). Significant differences in the rate of cancer association were present between the regenerative hyperplasia (22.2%) and adenomatous hyperplasia (57.9%). The incidence of benign lesions increased proportionally with the concentration of milk in the diet, especially in regenerative hyperplasia. In the group which had been given the lowest concentration of milk there was a significant increase of the serum gastrin level in the rats with gastric cancer or precancerous benign lesions like regenerative hyperplasia or adenomatous hyperplasia.
MNNG 투여에 의한 백서 위십이지장암 발생에 있어서 우유의 영향을 조사하고 그 원인을 분석키 위해 조직학적 및 혈청학적 분석을 시도하였다. 실험군은 생후 8주 전후의 Sprague-Dawley 백서 136마리로서 일반사료만 준 대조군 20마리(제 1군)와 6% 우유사료만 준 군 20마리(제 2군), MNNG