약학회지 (YAKHAK HOEJI)
- 제34권6호
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- Pages.439-446
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- 1990
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
효모에서 발현된 유전자 재조합 인간 성장호르몬의 일반 약리작용
General Pharmacology of Recombinant Human Growth Hormone Expressed in Saccharomyces cerevisiae
-
이은방
(서울대학교 생약연구소)
;
-
신국현
(서울대학교 생약연구소)
;
- 정명숙 (서울대학교 생약연구소) ;
- 김운자 (서울대학교 생약연구소) ;
- 윤기영 (서울대학교 생약연구소) ;
- 김정근 (서울대학교 생약연구소)
-
Lee, Eun-Bang
(Natural Products Research Institute, Seoul Natinal University)
;
-
Shin, Kuk-Hyun
(Natural Products Research Institute, Seoul Natinal University)
;
- Chung, Myung-Sook (Natural Products Research Institute, Seoul Natinal University) ;
- Kim, Oon-Ja (Natural Products Research Institute, Seoul Natinal University) ;
- Yoon, Ki-Young (Natural Products Research Institute, Seoul Natinal University) ;
- Kim, Jung-Keun (Natural Products Research Institute, Seoul Natinal University)
- 발행 : 1990.12.28
초록
The general pharmacological actions of recombinant human growth hormone (rHGH) were investigated. It had hypothermic action but neither sedative nor analgesic action. No pharmacological effects were observed in isolated guinea pig ileum and tracheal muscle and rat fundus and uterus. Slight hypotensive action with no effect on respiration was revealed at a dose of 20 IU/kg i.v. of rHGH in rabbits. The rHGH exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats 20 min after i.v. administration (80IU/kg), and produced a significant inhibitory effect on in vitro glycerol release in epinephrine-stimulated epididymal fat pad segments of rats.