약학회지 (YAKHAK HOEJI)
- 제34권6호
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- Pages.407-414
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- 1990
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Flavonoids의 약리작용(II) -항염작용과 창상치유 억제작용과의 상관성-
Pharmacological Activities of Flavonoids(II) -Relationships of Anti-inflammatory and Antigranulomatous Actions-
- Kim, Chang-Johng (College of Pharmacy, Chung-Ang University) ;
- Su, Soo-Kyung (College of Pharmacy, Chung-Ang University) ;
- Joo, Jae-Hyun (College of Pharmacy, Chung-Ang University) ;
- Cho, Seung-Kil (College of Pharmacy, Chung-Ang University)
- 발행 : 1990.12.28
초록
The relationships of inhibitory activities of inflammation and wound healing of flavonoids were studied in vitro and in vivo. Generally flavonoids have not only significantly anti-inflammatory activity in carrageenin-induced paw edema and Freund's complete adjuvant-induced arthritis, but also inhibitory activity of wound healing. The more inhibitory activities of wound healing flavonoids have, the more they have the anti-inflammatory activities; apigenin > guercetin > flovone > rutin > hesperidin > naringin. Their inhibitory mechanism seems to be inhibition of the inflammatory cell infiltration and fibroblast proliferation, and so they decreased the granulomatous activity and tensile strength.
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