YAKHAK HOEJI (약학회지)
- Volume 34 Issue 5
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- Pages.323-333
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- 1990
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
The Effect of Carbon Monoxide Intoxication on the Changes in Contents of Amino Acid Neurotransmitter of Rat Brain
일산화탄소 중독이 뇌내 아미노산 신경전달물질 함량변화에 미치는 영향
- Jung, Min-Jung (College of Pharmacy, Ewha Women's University) ;
- Park, Son-Ja (KIST, Doping Control Center) ;
- Lee, Sun-Hee (College of Pharmacy, Ewha Women's University) ;
- Yun, Jae-Soon (College of Pharmacy, Ewha Women's University)
- Published : 1990.10.28
Abstract
To study influence of carbonmonoxide (CO) poisoning on the content of amino acid neurotransmitter in brain, male rat was exposed to CO 5000 ppm for 30 minutes (60-75% HbCO). Aspartic acid and glutamic acid level in the cerebral cortex and aspartic acid level in the striatum were significantly decreased. GABA level in the cerebral cortex was significantly increased after the 30 and 60 minutes of CO intoxication. Taurine level in both the cerebral cortex and the striatum was increased although nonsignificant. Consequently, the CO-induced hypoxia brain showed lower level of excitatory neurotransmitter, aspartic acid and glutamic acid and higher level of inhibitory neurotransmitter, GABA and taurine. These results suggest that the change in content of amino acid neurotransmitter in the rat brain may be concerned with several CO poisoning symptoms.
Keywords
- Amino acid neurotransmitter;
- aspartic acid;
- glutamic acid;
- taurine;
- ${\gamma}-aminobutyric$ acid;
- CO intoxication