The Isolation and Evaluation of Bioactive Components from Crude Drugs Against a Cariogenic Bacterium, Streptococcus mutans OMZ 176(2) -An Antibacterial Component of Polygoni Radix and Its Safety-

충치균에 대한 생리활성 생약성분의 분리 및 약효평가(2) -호장근의 항균성분과 안전성에 대하여-

The isolation and identification of an antibacterial component, from Polygoni Radix against a cariogenic bacterium Streptococcus mutans OMZ 176, were carried out for development of anticariogenic agents. The bioactive component was identified to be emodin. The minimal inhibitory concentration (MIC) of emodin was $100\;{\mu}g/ml$ against S. mutans OMZ 176. The bioactive component emodin weakly inhibited ${\beta}-lactamase$ activity with the inhibition ratio of 1.7, 4.3 and 7.6% at the concentration of 50, 100, and 200 uM, respectively. Emodin exhibited slight phototoxicity when analysed by the photohemolysis method.