YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and Antimicrobial Activity of $7{\beta}-Diphenyl$ Triazolyl Thioacetamido Cephalosporin

$7{\beta}$-Diphenyl Triazolyl Thioacetamidocephalosporin의 합성과 항균작용

  • Kim, Young-Soo (Department of Pharmacy, Collage of Pharmacy, Chosun University) ;
  • Ko, Ok-Hyun (Department of Pharmacy, Collage of Pharmacy, Chosun University) ;
  • Kang, Hyung-Ryong (Department of Pharmacy, Collage of Pharmacy, Chosun University)
  • Published : 1990.04.30
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Abstract

$7{\beta}$-[4-Phenyl-5-(3.4.5-trimethoxyphenyl)-4H-1.2.4-triazol-3-yl]thioacetoamidocepharosporanic acid was synthesized by condensation of 7-Aminocephalosporanic acid (7-ACA) with [4-Phenyl-5-(3.4.5-trimethoxyphenyl)-4H-1.2.4-triazol-3-yl] thioacetylchloride. This compound was tested for antimicrobial activity in vitro against nine species of microorganisms. It showed remakable antibacterial activity against Bacillus subtilis, Micrococcus luteus, and Staphylococcus aureus.

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