YAKHAK HOEJI (약학회지)
- Volume 34 Issue 2
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- Pages.112-116
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- 1990
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Effect of Phenazine Dioxide Derivatives on the Hepatic Xanthine Oxidase Activity
Phenazine dioxide 유도체가 간 Xanthine Oxidase 활성에 미치는 영향
- Kang, Il-Young (Department of Organic Chemistry, College of Pharmacy, Hyosung Women's University) ;
- Kim, Sang-Yul (Department of Organic Chemistry, College of Pharmacy, Hyosung Women's University) ;
- Kim, Ho-Shik (Department of Chemistry, Teachers College, Hyosung Women's University) ;
- Huh, Keun (Department of Pharmacology, College of Pharmacy, Yeungnam University)
- Published : 1990.04.30
Abstract
8-Acyl-2-hydroxyphenzaine -5, 10-dioxides and 8-acyl-2-aminophenazine-5, 10-dioxides bearing n-butanoyl, n-hexanoyl and n-octanoyl groups were synthesized. It was attempted to observe the effect of phenazine dioxide derivatives on the hepatic xanthine oxidase activity in this study. As the activity of xanthine oxidase, the key enzyme in the generation of superoxide anion radical (