The Korean Journal of Pain
- 제2권2호
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- Pages.194-197
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- 1989
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- 2005-9159(pISSN)
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- 2093-0569(eISSN)
경피적 Scopolamine 부착제제가 경막외 Morphine 사용후 동반되는 구역과 구토에 미치는 영향
Therapeutic Effect of Transdermal Scopolamine Patch on Nausea and Vomiting Associated with Epidural Morphine
- 우남식 (건국대학교 의과대학 마취과학교실)
- Woo, Nam-Sick (Department of Anesthesiology, Kon Kuk University College of Medicine)
- 발행 : 1998.11.18
초록
Epidural morphine provides excellent analgesia for the management of postoperative pain, but nausea and vomiting are a commonly reported side effect. Scopolamine, a belladona alkaloid, is an effective antiemetic when nausea is induced by morphine. Transdermal scopolamine patches have the advantage of delivering a constant low dosage of the drug over a prolonged period. To evaluate the efficacy of prophylacitic transdermal scopolamine in reducing nausea or vomiting associated with postoperative epidural morphine analgesia, I studied 60 healthy adult patients. The patients were divided into 3 groups, each group consisting of 20 patients. Group 1; no scopolamine for control Group 2; transdermal scopolamine placebo patch Group 3; transdermal scopolamine patch All patients were anesthetized by epidural injection of 2% lidocaine 15 ml and 0.5% bupivacaine 10 ml with morphine 4 mg. A Comparison with the control group, the placebo group, and Group 3, indicated, that the transdermal scopolamine reduced the incidence of nausea or vomiting associated with postoperative epidural morphine analgesia (group 1; 35%, group 2; 25%, group 3; 10%). However there were no statistically significant differences between groups at a level of p>0.05.
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