Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Effect of Hyperbaric Oxygenation on Pulmonary Superoxide Dismutase Activity in Neonatal and Adult Rats

고압산소환경이 신생 및 성숙백서의 폐 superoxide dismutase 활성도에 미치는 영향에 관한 실험적 연구

  • Ahn, Hyeong-Sik (Department of Preventive Medicine, College of Medicine, Seoul National University) ;
  • Cho, Soo-Hun (Department of Preventive Medicine, College of Medicine, Seoul National University) ;
  • Yun, Dork-Ro (Department of Preventive Medicine, College of Medicine, Seoul National University) ;
  • Lee, Dong-Ryool (Department of Pharmacology, College of Medicine, Seoul National University) ;
  • Kim, Yong-Sik (Department of Pharmacology, College of Medicine, Seoul National University)
  • 안형식 (서울대학교 의과대학 예방의학교실) ;
  • 조수헌 (서울대학교 의과대학 예방의학교실) ;
  • 윤덕로 (서울대학교 의과대학 예방의학교실) ;
  • 이동율 (서울대학교 의과대학 약리학교실) ;
  • 김용식 (서울대학교 의과대학 약리학교실)
  • Published : 1989.03.01
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Abstract

To investigate the effect of hyperbaric oxygenation on superoxide dismutase activity, neonatal rats (7-10 days old) and adult rats (approximately 100 days old) were continuously exposed to hyperbaric oxygen environment of 2.4ATA for 8 hours and their superoxide dismutase activity were measured. Neonatal rats, all survived through exposure, showed significant increases in the pulmonary superoxide dismutase activity at immediately and 24 hours after exposure. Adult rats, whose 8 hour survival rates were 14%, did not show any significant increase in the activity of pulmonary superoxide dismutase as compared to the control adult rats. These findings are indicating that increased tolerance to oxygen toxicity in neonatal animals during exposure may be attributed to the increase in activity of superoxide dismutase in neonatal rats.

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