Clinnamic Acid Derivatives II, The Kinetics and Mechanism of the Hydrolysis of Benzalacetophenone Derivatives

신남산 유도체 II, Benzalacetophenone 유도체의 가수분해 메카니즘과 반응속도론적 연구

The Kinetics of the Hydrolysis of benzalacetophenone derivatives has been investigated by ultraviolet spectrophotometry in 5% dioxane - $H_2O$ at $50^{\circ}C$. A rate equation which can be applied over wide pH range was obtained. The substituent effect on the hydrolysis of benzalacetophenone derivatives were facilitated by electron attracting groups. Based on the rate equation, substituent effect, general base effect, activation parameters and final product, the hydrolysis of benzalacetophenone derivatives seems to be initiated by the netural molecule of $H_2O$ which does not dissociate at below pH 9.0 but proceeded by the hydroxide ion at above pH 11.0. In the range of pH $9.0{\sim}11.0$ these two reactions occur competitively.