Bulletin of the Korean Chemical Society

  • 제10권5호
  • /
  • Pages.434-437
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  • 1989
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  • 0253-2964(pISSN)
  • /
  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Proton Transfer Equilibria in The Excited State of Piroxicam and Its Analog in Aqueous Solution

  • Yoon, Min-Joong (Department of Chemistry, College of Natural Sciences, Chungnam National University) ;
  • Kim, Yong-Hee (Department of Chemistry, College of Natural Sciences, Chungnam National University)
  • 발행 : 1989.10.20
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초록

The pH dependence of the absorption and fluorescence of 4-hydroxy-2-methyl-1,2-benzothiazinenecarboxylat es, piroxicam and HMBDC have been measured and compared with the solvent dependence of the spectra reported previously. Four different prototropic species are observed in both ground and excited states of piroxicam ; the cation, the neutral, the anion and the dianion, while three different species such as the cation, the neutral and the anion are observed in HMBDC. The $pK_a$ and $pK_a^{\ast}$ have been determined by absorptiometric titration and Forster cycle method, respectively. The probable structure of each species has been proposed on the basis of the intramolecular phototautomerism.

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참고문헌

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피인용 문헌

  1. Fluorescence Piroxicam Study in the Presence of Cyclodextrins by Using the PARAFAC Method vol.53, pp.5, 1989, https://doi.org/10.1366/0003702991947054
  2. Spectrophotometric Study of Acidity and Complex Formation of Anti-Inflammatory Drug Piroxicam with Some Transition Metal Ions in Different Methanol/Water Mixtures by Chemometric Methods vol.53, pp.6, 1989, https://doi.org/10.5012/jkcs.2009.53.6.693
  3. A theoretical and spectroscopic study of conformational structures of piroxicam vol.75, pp.2, 2010, https://doi.org/10.1016/j.saa.2009.12.031
  4. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Piroxicam vol.103, pp.2, 1989, https://doi.org/10.1002/jps.23799
  5. Photophysical properties of anti‐inflammatory piroxicam and its Cu( II ) complex vol.42, pp.12, 1989, https://doi.org/10.1002/bkcs.12413