Bulletin of the Korean Chemical Society

  • 제10권4호
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  • Pages.331-335
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  • 1989
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Peptide Synthesis with Polymer Bound Active Ester. I. Rapid Synthesis of Peptides Using Polymer Bound 1-Phenyl-3-methyl-4-oximinopyrazole

  • Lee, Ki-Wha (Department of Chemical Technology, College of Engineering, Seoul National University) ;
  • Lee, Yoon-Sik (Department of Chemical Technology, College of Engineering, Seoul National University)
  • 발행 : 1989.08.20
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초록

Polymer bound 1-phenyl-3-methyl-4-oximinopyrazoles were prepared through a series of chemical modifications of Merrifield's resin (chloromethylpolystyrene-$1{\%}$ DVB-copolymer). Several polymer active esters of N-blocked amino acids were prepared from the polymer bound 1-phenyl-3-methyl-4-oximinopyrazoles. Polymer bound active esters were found to be highly reactive in N-acylation reaction. The resins were tested for the preparation of several dipeptides. The peptides were obtained in high yields within 10 minutes and the progress of the reactions could be easily followed up by the color change of the resin. The resulting peptides were characterized by NMR and other physical methods.

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참고문헌

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피인용 문헌

  1. Preparation of polymer-bound pyrazolone active esters for combinatorial chemistry vol.44, pp.44, 1989, https://doi.org/10.1016/j.tetlet.2003.09.044
  2. A Concise Review on the Synthesis and Reactions of Pyrazolopyrazine Heterocycles : Pyrazololpyrazines: Synthesis and Reactions vol.55, pp.8, 1989, https://doi.org/10.1002/jhet.3225
  3. Efficient synthesis of some novel furo[3,2-e]pyrazolo[3,4-b]pyrazines and related heterocycles vol.48, pp.4, 1989, https://doi.org/10.1080/00397911.2017.1403626
  4. A convenient synthesis, reactions and biological evaluation of novel pyrazolo[3,4-b]selenolo[3,2-e]pyrazine heterocycles as potential anticancer and antimicrobial agents vol.29, pp.12, 2020, https://doi.org/10.1007/s00044-020-02635-z