Enzymatic Hydrolysis of$\beta$-Lactam Esters by PLE

Shim Young Key;Shim Joong-Youn;Cho Young Soon;Kim Wan Joo;

doi:10.5012/bkcs.1989.10.1.33

Bulletin of the Korean Chemical Society

Volume 10 Issue 1
/
Pages.33-34
/
1989
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0253-2964(pISSN)
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1229-5949(eISSN)

Korean Chemical Society (대한화학회)

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Enzymatic Hydrolysis of$\beta$-Lactam Esters by PLE

Shim Young Key (Korea Research Institute of Chemical Technology) ;
Shim Joong-Youn (Korea Research Institute of Chemical Technology) ;
Cho Young Soon (Korea Research Institute of Chemical Technology) ;
Kim Wan Joo (Korea Research Institute of Chemical Technology)

심영기 (한국화학연구원) ;
심중윤 (한국화학연구원) ;
조영순 (한국화학연구원) ;
김완주 (한국화학연구원)

Published : 19890200

https://doi.org/10.5012/bkcs.1989.10.1.33 Citation PDF

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Abstract

Pig Liver Esterase (PLE) which has been known to cleave a broad range of diesters to prepare stereoselective enantiomers is applied to hydrolysis of ${\beta}-lactam$ esters imparting the corresponding acids in various yields.

Keywords

References

Enzymes as Catalysts in Organic Synthesis M. Ohno;S. Kobayashi;Adachi;M. P. Schneider(ed.)
Nippon Kagaku Kaishi v.9 A. Hazato;T. Tanaka;T. Toru;N. Okamura;K. Bannai;S. Sugiura;K. Manabe;S. Kurozumi
Recent Advances in the Chemistry of ${\beta}$-Lactam Antibiotics A. H. Shingler;N. G. Weir;J. Elks(ed.)
Tetrahedron Lett. v.21 D. G. Melillo;I. Shinkai;T. Liu;K. Ryan;M. Sletzinger

Cited by

E/Z-Diastereoselektive enzymatische Hydrolyse von Estern und Diestern vol.105, pp.4, 1989, https://doi.org/10.1002/ange.19931050429