Modifying Effects of Capsaicin, Allyl Sulfide, Indole-3-Carbinol and Germanium on the Induction of Pepsinogen 1 Altered Pyloric Glands in Rats Initiated with N-Methyl-N`-Nitro-N-Nitrosoguanidine

Capsaicin, Allyl Sulfide, Indole-3-Carbinol 및 Germanium의 MNNG 유발랫트 펩시노젠 1변이 위 유문선 발현 수식효과

Quantitative analyses were made of pepsinogen 1 (Pg 1) decreased pyloric glands after treating male Wistar rats with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and NaCl and then with various test chemicals. Animals received MNNG in drinking water (100ng/ml) and 10% NaCl in diet for 8 weeks (group1), followed by basal diet containing 0.01% capsaicin, 0.5% allyl sulfide, 0.5% indole-3-carbinol and 0.05% germanium until 20 weeks (groups 2-5).