저온 메탈플라스마 전처리 견피브로인 막에의 메틸메타크릴레이트 및 스티렌의 그라프트 공중합, 막의 표면장력 및 항혈전성

Surface Tension and Antithrombogenicity of Silk Fibroin Films Graft-Copolymerized with Methyl Methacrylate and Styrene by Cold Methane Plasma Initiation

Silk fibroin was dissolved in calcium chloride/ethanol/water mixture(1/2/8 in mole ratio)at 7$0^{\circ}C$ for 4hrs. The dissolved silk fibroin was regenerated by casting the dialyzed solution into the film. The films were treated with 50% aqueous methanol solution for 15 min. Then the films were graft-copolymerized with methylmethacrylate and styrene by methane plasma initiation and their antithrombogenicities were investigated by the methods of blood clotting and platelet adhesion tests. The results from the two "in vitro" tests were analyzed in connection with surface tension of the film. It was found that the antithrombogenicity of films was improved by the surface grafting and varid with the fraction of polar component of surface tension to the total surface tension of film.n of film.