불순응된 토양에서 이메틸벤조안트라센 돌연변이 유발성의 불활성화

Mutagenic Deactivation of 7, 12-Dimethylbenz(a)anthtacene in Nonacclimated Soil

불순응된 사질토에서 7,12 - 이메틸벤조안트라쎈 돌연변이 유발성의 불활성화에 대한 연구가 행해졌다. 토양에서 형성된 이메틸벤조아트라센의 극성이 강한 대사산물은 Ames분석에서 돌연변이성을 나타내지 않았다. 극성이 중간 또는 약한 대사산물은 돌연변이성을 보였으며, 그 변이비는 모체화합물의 변이비와 유사하였다.

Mutagenic characteristics deactivation of 7, 12-dimethylbenz(a)anthraracene was studied in a nonacclimated sandy loam soil at low and neutral pH soil conditions. Soil extracts containing transformation products were separated into three fractions based on HPLC retention time(polarity). Highly polar transformation products of 7, 12-dimethylbenz(a)anthracene demonstrated a negative mutagenic response with the Ames mutagenicity assay, strain TA-100, for both low and neutral pH soils. Moderate and low polar fractions, however, induced mutagenicity for both soil samples with mutagenic ratios similar to those of the parent compound.