Toxicological Research
- 제5권2호
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- Pages.71-77
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- 1989
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
TOXICITY STUDY ON CHINESE HERBAL DRUGS USING THE MICRONUCLEUS ASSAY IN MURINE BONE MARROW ERYTHROCYTES
- Ian C. Guest (Graduate School of Public Health, Seoul National University) ;
- Yoo, Sang-Ou (Graduate School of Public Health, Seoul National University) ;
- Paik, Nam-Woo (Graduate School of Public Health, Seoul National University) ;
- Lee, Young-Wook (Graduate School of Public Health, Seoul National University) ;
- Oh, Ki-Bong (Graduate School of Public Health, Seoul National University) ;
- Yang, Heyong-Cheol (Graduate School of Public Health, Seoul National University) ;
- Suh, Nan-Joo (Natural Products Research Institute, Seoul National University) ;
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Chang, Il-Moo
(Natural Products Research Institute, Seoul National University)
- 발행 : 1989.12.01
초록
A mouse whole animal bioassay was employed to screen for potential mutagenicity of ethanol/water extracts of 16 Chinese herbal drugs that are commonly prescribed in Korea. Specific cytogenetic toxicity was measrured by recording evidence of clastogenesis toxicity was measured by recording evidence of clastogenesis via the mouse bone marrow micronucleus test. Male ICR mice administered ethanol extract of Pinelliae tuber (Pinellia eternata Breitenbach, ARACEAE, 양복) and ddY female mice administered extract of Angelica Koreanae radix(Angelica Koreana Maximowicz, UMBELLIFERAE, ) (both by oral administration, at a dose of 600 mg/kg), in a short-term dosing schedule, demonstrated significant increase in micronucleated polychromatophilic erythrocytes, indicating the increase of clastogenicity.
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