Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and Biological Effects of 2, 3-Diphenyl-5-Methoxyindole and Substituted Benzophenone Derivatives

  • Hishmat, O.H. (Natural Products Department National Research Centre) ;
  • El-Sbabrawy, O.A. (Pharmacology Department National Research Centre) ;
  • Nakkady, S.S. (Natural Products Department National Research Centre) ;
  • Mahmoud, S.S. (Pharmacology Department National Research Centre)
  • Published : 1989.09.01
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Abstract

Seven 2, 3-diphenyl-5-methoxyindole derivatives were synthesized. The effect of structural variation of these molecules on biological activities was examined. None of the tested compounds was found to be toxic up 5 gm/Kg body weight. Four compounds demonstrated smooth muscle relaxant effects and one showed a persistent hypotensive effect. Only the parent compound, 2, 3-diphenyl-5-methoxyindole, showed a significant analgesic effect.

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