Archives of Pharmacal Research
- Volume 12 Issue 3
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- Pages.149-153
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- 1989
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and Biological Effects of 2, 3-Diphenyl-5-Methoxyindole and Substituted Benzophenone Derivatives
- Hishmat, O.H. (Natural Products Department National Research Centre) ;
- El-Sbabrawy, O.A. (Pharmacology Department National Research Centre) ;
- Nakkady, S.S. (Natural Products Department National Research Centre) ;
- Mahmoud, S.S. (Pharmacology Department National Research Centre)
- Published : 1989.09.01
Abstract
Seven 2, 3-diphenyl-5-methoxyindole derivatives were synthesized. The effect of structural variation of these molecules on biological activities was examined. None of the tested compounds was found to be toxic up 5 gm/Kg body weight. Four compounds demonstrated smooth muscle relaxant effects and one showed a persistent hypotensive effect. Only the parent compound, 2, 3-diphenyl-5-methoxyindole, showed a significant analgesic effect.
Keywords
- 2,3-Diphenyl-5-methoxyindole derivatives;
- substituted benzophenones;
- toxicity;
- smoth muscle relaxant effect;
- hypotensive;
- analgesic activity