Journal of Pharmaceutical Investigation
- Volume 19 Issue 4
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- Pages.203-212
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- 1989
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- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
Studies on Higher Fungi in Korea (Vl)-Studies on Proteolytic Enzyme Preparation Using Sarcodon aspratus Extract-
한국산 고등균류에 관한 연구(제 6보)-능이버섯 중 단백분해효소의 제제화에 관한 연구-
-
Yang, Jae-Heon
(Department of Pharmacy, Jeonju Woosuk University)
;
-
Eun, Jae-Soon
(Department of Pharmacy, Jeonju Woosuk University)
;
- Her, Jung-Duk (Department of Pharmacy, Jeonju Woosuk University)
- Published : 1989.12.20
Abstract
A proteolytic enzyme was extracted from Sarcodon aspratus (Berk) S. Ito by percolation method. Proteolytic activity of the extracted proteolytic enzyme (SAP) was compared with several digestives containing proteolytic enzymes. Potency of SAP was higher than that of the other digestives except for protease. The optimum pH ranse of SAP was similar to that of pancveatin and protease. SAP was more stable than pancreatin and protease under various temperature, alkaline pH, and metal ions. Bovine serum albumin hydrolysing activity of SAP was equivalent to that of pancreatin and protease in small intestine of rats. SAP demonstrated lower adsorption to antacids than pancreatin and protease. Among the mixtures of SAP and several antacids, magnesium oxide-SAP showed the highest proteolytic activity.
Keywords
- Sarrodon aspratus (Berk) S. Ito;
- extract;
- pancreatin;
- protease;
- proteolytic activity;
- stability;
- intestinal hydrolysis and absorption;
- antacids