Acrylamide-Styrene Copolymer 하이드로겔로부터의 수팽윤 속도조절에 의한 약물 방출

Swelling Controlled Drug Release from Acrylamide-Styrene Copolymer Hydrogels

Drug release rates from copolymer hydrogels were controlled by their hydrophilic-hydrophobic balances. As a model copolymer hydrogel, poly(acrylamide-co-styrene) was synthesized at different monomer composition. Release mechanisms of propranolol-HCI from the copolymer matrices were investisated. Swelling rates of the copolymer hydrogels retarded as their hydrophobicity increased. Swelling kinetics of the copolymer hydrogels regulated drug release rates via polymer relaxation controlled release mechanisms. Zero order drug release could thus be achieved within certain periods.