Drug Interaction of Sulfonamides and Furosemide (I)-Displacement Effect of Furosemide on Protein Binding of Sulfonamides in Bovine Serum Albumin-

설파제와 푸로세미드 약물상호작용(제 1보)-설파제의 우혈청 단백결합에 대한 푸로세미드의 치환효과-

The displacement of protein bound sulfonamides (sulfisoxazole, sulfamethoxazole, sulfisomidine) by furosemide was investigated in bovine serum albumin by equilibrium dialysis method. Furosemide $(2{\times}10^{-4}M)$ in bovine serum albumin ($7.24{\times}10^{-5}$, $1.45{\times}10^{-4}$, $2.89{\times}10^{-4}M$). Sulfisoxa캐1e and furosemide were bound reversibly to bovine serum albumin and competitive for the same binding sites when administered together. Consequently, dosage regimen of sulfisoxazole should be adjusted carefully when sulfisoxazole is administered along with furosemide.