한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition)
- 제18권1호
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- Pages.1-13
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- 1989
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- 1226-3311(pISSN)
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- 2288-5978(eISSN)
어유식이가 본태성고혈압쥐(SHR)혈압 및 지질대사에 미치는 영향 -혈청지질상태를 중심으로-
Effect of Fish Oil Diet on Blood Pressure and Lipid Metabolism in Spontaneously Hypertensive Rat -Changes in Serum Lipid Status-
- Shin, Eung-Nam (Dept. of Food Science and Nutrition, Hyosung Women's University) ;
- Bae, Bok-Seon (Dept. of Food Science and Nutrition, Hyosung Women's University) ;
- Lee, Won-Jong (Dept. of Physiology, School of Medicine, Kyungbuk National University) ;
- Cho, Sung-Hee (Dept. of Food Science and Nutrition, Hyosung Women's University)
- 발행 : 1989.03.01
초록
The present study was designed to examine the effect of dietary fish oil on blood pressure and lipid status of serum. Weanling SHRs and normotensive Wistars were fed a diet containing 5%(w/w) mackerel oil(MO), soybean oil(SO) or beef tallow(BT) for 8 weeks. Growth rate was not significantly different among three dietary groups, but that of SHRs was silightly lower than that of Wistars. SHRs showed higher systolic blood pressure than Wistar rats from the beginning and become hypertensive (over 150mmHg) after 6 week s of feeding period. The MO group of SHRs showed the lowest blood pressure at the 8th week of feeding period but that of Wistars showed similar values with other groups. Tissue weights of liver, heart and kidney were not different amongdietary aroups in Wistars and SHRs. However, heart and kidney weights of SHRs were significantly higher than those of Wistars. Microscopic examination revealed that endomysium of heart tissue and urinary space of kidney were narrowed in SHRs. Serum total and HDL-cholesterol showed similar values among three different dietary fat groups but triglyceride levels were significantly low in MO groups. HDL-cholesterol levels of SHRs were lower than those of Wistars, as well as the fractions of total HDL, the sum of HDL and
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