Effects of Ginsenosides on the Development of Morphine-induced Tolerance and Physical Dependence in Mice

  • Published : 1989.06.30

Abstract

The effects of ginsenosides on the development of morphine induced tolerance and physical dependence were investigated. $Rb_1,\;Rb_2,\;Rg_1\;and\;Re$ inhibited significantly the development of morphine induced tolerance but $Rb_1\;and\;Rg_1$ showed significant inhibitory effect on the naloxone induced withdrawal jumping response. Ginsenosides inhibited the body weight decrease in physically dependent mice during multiple injection of morphine.

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