The Korean Journal of Pharmacology (대한약리학회지)
- Volume 25 Issue 1
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- Pages.67-74
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- 1989
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- 0377-9459(pISSN)
Influence of Endogenous Catecholamines on Guanabenz- lnduced Inhibition of Micturition Reflex in Rats
Guanabenz 투여에 의한 흰쥐의 배뇨반사억제작용에 미치는 내인성 Catecholamines의 영향
- Park, Sang-Yeoul (Department of Pharmacology, School of Medicine, Kyungpook National University) ;
- Sohn, Uy-Dong (Department of Pharmacology, School of Medicine, Kyungpook National University) ;
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Kim, Choong-Young
(Department of Pharmacology, School of Medicine, Kyungpook National University)
- Published : 1989.06.30
Abstract
The effect of guanabenz on volume-induced micturition reflex contraction (VIMRC) in urethane-anethetized female rats was examined under adrenalectomy, chemical-sympathectomy, ganglionectomy, alpha-1, or alpha-2 blockade. Intracerbroventricular administration of guanalberz had little effect on VIMRC, but topical application suppressed amplitude and frequency of VIMRC. Guanabenz intravenous injection dose-dependently suppressed amplitude and frequency of VIMRC, with complete inhibition at dose of
배뇨반사수축에 미치는