Synthesis and Structure of Purine Derivatives as Antitumor Effects

  • Moharram, H.H. (National Organisation for Drug Control and Research) ;
  • El-Bayouki, Khairy A.M. (National Research Center, Cairo, and Cancer Institute, Cairo University) ;
  • Haggag, B. (National Research Center, Cairo, and Cancer Institute, Cairo University) ;
  • Basyouni, W.M. (National Research Center, Cairo, and Cancer Institute, Cairo University) ;
  • Osman, A.M. (National Organisation for Drug Control and Research)
  • Published : 1989.06.01

Abstract

The nucleophilic substitution reaction of 6-chloro purines (I) with malononitrile and ethyl cyanoacetate is carried out in DMSO and in the presence of an alkali. The possible tautomeric-ylidene form for the products is considered and discussed in view of IR, UV, NMR and mass spectral determinations. The derivatives were tested for their antitumor activities.

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