Archives of Pharmacal Research
- Volume 12 Issue 1
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- Pages.12-16
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- 1989
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
New Synthesis of Chromonopyrroloimidazolinones and Arylidene Thioxoimidazolinones -Study of their antimicrobial activities-
- Abdel Aziz, Mahfouz A. (Chemistry Department, Faculty of Science, Cairo University) ;
- Riad, Bahia Y. (Chemistry Department, Faculty of Science, Cairo University) ;
- Shalaby, A.M. (Botany Department, Faculty of Science, Cairo University)
- Published : 1989.03.01
Abstract
6-Formyl-5-methoxy-2-methyl chromone derivatives condensed with 2-thiox-4-imidazolinone derivatives to form the corresponding '10-methoxy-7-methyl-3-thioxo-chromone[6,7-b]pyrrolo[1,2-a-]-imidazolin-1-one derivatives (IIIa-f) or the 5-arvlidene-2-thioxo-4-imidazolinone derivatives(IVa-f). The activity of the NH in the imidazol moiety of (IIIa) was confirmed by formation of the Mannich bases (Va, b). Moreover, alkylation of (IIIa) was undertaken to give the alkylmercapto derivatives (VIa, b). The antimicrobial activities of compounds IIIb-e, IVa, IVe were studied.
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