YAKHAK HOEJI (약학회지)
- Volume 33 Issue 3
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- Pages.191-202
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- 1989
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Microencapsulation of Indomethacin by Pectin-Gelatin Complex Coacervation Method
Pectin-Gelatin Complex Coacervation 에 의한 Indomethacin의 Microencapsulation 에 관한 연구
- Ku, Young-Soon (College of Pharmacy, Ewha Womans University) ;
- Chin, Soo-Young (College of Pharmacy, Ewha Womans University)
- Published : 1989.06.28
Abstract
Indomethacin, a non-steroidal antiinflammatory drug inducing gastric irritation, was microencapsulated using pectin-gelatin complex coacervation method. Optimum conditions for microencapsulation and dissolution characteristics of the microcapsules were studied. The optimum pH and pectin-gelatin ratio for microencapsulation were 3.8 and 1:2 respectively. As concentration of colloid solution increased, wall thickness of microcapsules were increased. The dissolution rate of Indomethacin-pectin-gelatin microcapsules prepared by 1.5% and 2% colloid solution were similar but slower than that of Indomethacin-pectin-gelatin microcapsules prepared by 1% colloid solution. The 50% release time (