약학회지 (YAKHAK HOEJI)
- 제33권1호
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- Pages.64-71
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- 1989
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Tranylcypromine 광학이성질체에 의한 MAO 자살억제의 반응속도론
Suicidal Inhibition Kinetics of MAO by Tranylcypromine Enantiomers
- Kang, Gun-Il (College of Pharmacy, Sookmyung Women's University) ;
- Choi, Myung-Hee (College of Pharmacy, Sookmyung Women's University)
- 발행 : 1989.02.28
초록
Since time-dependent inactivation of MAO was found to be complete in a few minutes when high concentration ratios of tranylcypromine to MAO were used, a method to obtain kinetic parameters was sought suitable to the conditions in which concentrations of tranylcypromine analogs did not exceed that of MAO. For the purpose, kinetic equations were derived and the method applied to the kinetic studies of tranylcypromine enantiomers. It was found that (E)-(+)-2-phenylcyclopropylamine inhibited MAO by the mechanism following bimolecular reaction scheme with
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