The Effect of Eicosapentaenoic Acid on the Immune Response in Mice(II) -II. Cell-mediated immunity and Nonspecific Immunity-

마우스에 있어서 에이코사펜타엔산이 면역반응(免疫反應)에 미치는 영향(影響)(II) -II. 세포성(細胞性) 면역(免疫) 및 비특이적(非特異的) 면역(免疫)-

The cellular and nonspecific immune response of EPA were investigated in mice. ICR male mice were divided into 8 groups and received intraperiteneal injection of EPA (5 mg, 10 mg, 20 mg/kg) for 4 weeks. Cyclophosphamide (5 mg/kg) was administered i.p. 2days prior to secondary immunization. Immune responses were evaluated by hypersensitivity to SRBC(DTH), rosette forming cell(RFC), natural killer(NK) cell activity and macrophage activity. The obtanined results were as follows: As compared to normal group, 1) DTH was increased by EPA 5 mg, 10 mg administration groups. 2) RFC was significantly increased by EPA 20 mg administration group. 3) NK-Cell activity was significantly increased by EPA 10 mg administration group. 4) Macrophase activity was enhanced by EPA 5 mg administration group.