가토의 신장기능과 Renin 분비에 미치는 Adenosine수용체 차단제의 영향

Effect of Adenosine Receptor Antagonists on the Renal Function and Renin Release in Rabbits

  • 이건수 (충남대학교 의과대학 소아과학교실) ;
  • 김영진 (전북대학교 의과대학 생리학교실) ;
  • 김선희 (전북대학교 의과대학 생리학교실) ;
  • 조경우 (전북대학교 의과대학 생리학교실)
  • Rhee, Keon-Su (Department of Pediatrics, Chungnam National University Medical School) ;
  • Kim, Young-Jin (Department of Physiology, Jeonbug National University Medical School) ;
  • Kim, Suhn-Hee (Department of Physiology, Jeonbug National University Medical School) ;
  • Cho, Kyung-Woo (Department of Physiology, Jeonbug National University Medical School)
  • 발행 : 1989.12.30

초록

Recently it was suggested that the endogenous adenosine might be the mediator for the intercellular communication in the regulation of tubuloglomerular feedback control and renin release. Even though the previous data showed more important regulatory roles in the renal hemodynamics and renin release for the A1 adenosine receptor, it has not yet been settled down about the functional subclassification of renal adenosine receptors. The purpose of the present experiment was to clarify the importance of the renal adenosine receptors for the regulations of the hemodynamic, excretory and secretory functions. Experiments have been done in unanesthetized rabbits. Intrarenal arterial infusion of A1 adenosine antagonist, 8-phenyltheophylline, $3{\sim}30\;nmole/min$, increased urine flow, renal hemodynamics and urinary excretion of sodium. Intrarenal arterial infusion of Al antagonist, 1-3-diethyl-8-phenylxanthine (DPX), $10{\sim}100\;nmole/min$, increased renal hemodynamics and excretory functions. Non-specific adenosine antagonist, theophylline, $30{\sim}300\;nmole/min$, resulted in dose dependent increases in renal hemodynamics and excretory function. All of the three adenosine antagonists for the increases in renal hemodynamics, excretory and secretory functions was 8-phenyltheophylline > DPX > theophylline. These results suggest that the endogenous adenosine is important for the intrinsic regulatory roles for the renal functions through the adenosine receptors, and that the A1 adenosine receptor is more important than the A2 receptor in the regulation of renal hemodynamics, excretory and renin secretory functions.

키워드