The Korean Journal of Physiology
- Volume 23 Issue 2
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- Pages.329-337
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- 1989
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- 0300-4015(pISSN)
The Influence of Several Drugs Affecting $Ca^{2+}$ Influx on Frequency-tension Curve of Rat Left Atrium
쥐의 좌심방에서 세포막을 통한 $Ca^{2+}\;Flux$ 에 영향을 주는 약물이 자극빈도-장력 곡선에 미치는 영향
- Kim, Chan-Yun (Department of Physiology, Yonsei University College of Medicine) ;
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Ahn, Sok-Kyun
(Department of Physiology, Yonsei University College of Medicine) ;
- Suh, Chang-Kook (Department of Physiology, Yonsei University College of Medicine) ;
- Kang, Doo-Hee (Department of Physiology, Yonsei University College of Medicine)
- Published : 1989.12.30
Abstract
Cardiac muscles show stimulation frequency-dependent tension changes i.e. Bowditch phenomenon and Woodworth phenomenon, the former is an increase of tension with the increase of stimulation frequency, whereas the latter is an increase of tension with a decrease of stimulation frequency. Bowditch phenomenon is seen in the range of frequency 1.0 cps and above, and Woodworth phenomenon below the frequency 1.0 cps in the most of mammalian cardiac atrium. To throw some light on the possible mechanism of both phenomena in rat atrium, influences of drugs affecting