The Korean Journal of Physiology
- 제23권1호
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- Pages.151-167
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- 1989
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- 0300-4015(pISSN)
피부염에 의해 유발된 척수후각세포의 Activity 변동에 관한 연구
Modification in the Responsiveness of Cat Dorsal Horn Cells during Carrageenin-Induced Inflammation
- 김기순 (한양대학교 의과대학 생리학교실) ;
- 신홍기 (한양대학교 의과대학 생리학교실) ;
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김진혁
(한양대학교 의과대학 생리학교실) ;
- 이애주 (한양대학교 의과대학 생리학교실) ;
- 강석한 (한양대학교 의과대학 생리학교실)
- Kim, Kee-Soon (Department of Physiology, College of Medicine, Hanyang University) ;
- Shin, Hong-Kee (Department of Physiology, College of Medicine, Hanyang University) ;
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Kim, Jin-Hyuk
(Department of Physiology, College of Medicine, Hanyang University) ;
- Lee, Ae-Joo (Department of Physiology, College of Medicine, Hanyang University) ;
- Kang, Suck-Han (Department of Physiology, College of Medicine, Hanyang University)
- 발행 : 1989.06.30
초록
The present study was undertaken to investigate modification in electrophysiological characteristics of cat dorsal horn cells resulting from carrageenin-induced inflammation. The followings were studied; 1) the time-course of changes in responses of the WDR (wide dynamic range) cell 1-3h after subcutaneous injection of carrageenin in its receptive field; 2) the responses of the same dorsal hern cells before and after induction of inflammation; 3) the effect of inflammation on the responsiveness of dorsal horn neurons to algogens (bradykinin & potassium); and 4) the effect of inflammation on the activity of WDR cell following administration of indomethacin and clonidine. Though responses of WDR neuron were increased dramatically during first 1h, the maximal enhancement was observed 3h after induction of inflammation especially by repetitive light tactile stimulus. Following carrageenin injection the majority of WDR neurons (10/15 units) showed enhanced responses to all the mechanical stimuli while in 3 cases responsiveness were intensified during activation by one tactile stimulus (brush or pressure). One cell was unaffected by inflammation and in another case the response was enhanced only to noxious stimulus. Five of 9 cells that could initially be driven by noxious stimulus were activated more strongly by same stimulus and even by tactile stimulus (pressure) following inflammation. In 2 cases neurons were sensitized only to noxious stimulus whereas in another 2 cells that did not show enhanced responses to noxious stimulus responses to light tactile stimulus (pressure) appeared after inflammation. Of 16 LT cells tested 6 responded to squeeze while 4 showed the characteristics of WDR cell following inflammation. No modification in responsiveness was recognized in 3 cells whereas response to only brush was enhanced in another 3 neurons. Following carrageenin injection responses of LT cell to bradykinin or
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