대한치과교정학회지 (The korean journal of orthodontics)
- 제18권2호
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- Pages.329-342
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- 1988
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- 2234-7518(pISSN)
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- 2005-372X(eISSN)
실험으로 유도된 구개열 마우스의 안면골 성장에 관한 연구
A STUDY ON FACIAL BONE GROWTH OF PALATAL CLEFTS EXPERIMENTALLY INDUCED IN MICE
- 전윤식 (연세대학교 대학원 치의학과)
- Chun, Youn Sic (Department of Dental Science, Graduate School, Yonsei University)
- 발행 : 1988.09.30
초록
In methods of finding causes for cleft palate, many cases have been studied by investigators using teratogenic agents. Among them, a synthetic agent known as triamcinolone acetonide (TA) was widely used. When this drug was injected into mice during palatogenesis, it induced lowered body weight and a deformed mandible. But many cases have been studied on growth changes, only of the developmental stages of the palate. Therefore, the objective of this study was to evaluate craniofacial growth in experimentally induced cleft palate mice after finishing palatogenesis namely just before birth. Normal, alcohol treated, and TA treated DDY mice were obtained at 18-days of gestation and heads were prepared for serial sectioning in the sagittal plane. The midsagittal sections were photographically enlarged (
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