The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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Quantitative Evaluation of Liver Function Using $^{99m}Tc-DISIDA$ Cholescintigraphy

$^{99m}Tc-DISIDA$ 스캔에 의한 간기능의 정량적 평가

  • Kim, Chahng-Guhn (Department of Radiology, Wonkwang University School of Medicine) ;
  • Kim, Byung-Chan (Department of Radiology, Wonkwang University School of Medicine) ;
  • Chung, Young-Sun (Department of Radiology, Wonkwang University School of Medicine) ;
  • Won, Jong-Jin (Department of Radiology, Wonkwang University School of Medicine) ;
  • Rhee, Jeong-Kyun (Department of General Surgery, Wonkwang University School of Medicine)
  • 김창근 (원광대학교 의과대학 방사선과학교실) ;
  • 김병찬 (원광대학교 의과대학 방사선과학교실) ;
  • 정영선 (원광대학교 의과대학 방사선과학교실) ;
  • 원종진 (원광대학교 의과대학 방사선과학교실) ;
  • 이정균 (원광대학교 의과대학 일반외과학교실)
  • Published : 1988.11.25
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Abstract

Since hepatocyte clearance, leading edge parencymal transit time and biliary excretion can be evaluated separately with hepatobiliary scan using $^{99m}Tc-DISIDA$, hepatobiliary scan may be useful in differentiating intrahepatic cholestasis from extrahepatic cholestasis. Excretory liver function was analysed in 13 healthy subjects and 11 patients with clinically suspected hepatocellular disease and 9 patients with extrahepatic biliary obstruction confirmed by surgery, radiological and clinical evidence. Indices of total liver activity (% TLA), liver parechymal uptake (% LPU), heart pool clearance (% HPC) and liver-heart rate (% LHR) were calculated from time activity curve over heart and liver. Compared with healthy subjects, significant reduction (p<0.05) in total liver activity (% TLA) and liver-heart rate (% LHR) was observed in all patients group. But no useful indices was demonstrated in differentiating hepatocellular disease from extrahepatic biliary obstruction.

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